Events of The Last of UsEdit
Sometime after the outbreak, the hospital was used in an attempt to quarantine and isolate the infected. Some time afterwards, it was completely abandoned of infected and non-infected alike. The Fireflies later ran the hospital as their base of operations after abandoning the University of Eastern Colorado due to an outbreak of Infected overrunning the campus. It became their main base roughly 10 years before given by what is said in Marlene's diary.
The Fireflies cleared out the nearby surroundings though did not clear the entire city. This is shown by how places such as tunnels and sewers still possess infected, suggesting the Fireflies are low on supplies or are unable to takeover the entire city. This means that only the Hospital is free of Infected presense.
The majority of elite Fireflies seem to be based here given by the strength of their equipment such as assault rifles and body armour over the more basic Boston Fireflies who only had pistols and hunting rifles.
Sometime after the Boston battle, Marlene and the surviving Boston Fireflies all returned to the hospital by late March 2034.
After Joel and Ellie found out the Fireflies abandoned the University of Eastern Colorado, they headed to Salt Lake City. When they got there, the two Fireflies discovered them and took them to the hospital, one knocking Joel out before reviving Ellie and taking them to the hospital.
Marlene allowed Joel to recover in one on the hospital beds while she discussed with the head surgeon about Ellie's condition. Despite learning Ellie would have to die to obtain a vaccine, Marlene gave them permission regardless.
She returned to Joel's room with the Firefly Ethan, where she informed the now awake Joel that they had to surgically remove the fungus from Ellie's brain obtain the vaccine. Marlene left an angered Joel to be marched out of the hospital. Desiring to save Ellie, Joel disarmed and killed Ethan then fought his way through the various floors to reach Ellie, killing several Fireflies (player determined) and Marlene to do so. It is unknown what the Fireflies did with the hospital after this.
- When Joel reaches the top floor of the hospital, there is an eye test sign in one of the rooms. The letters spell out the message "you're almost there, you can do it, don't give up".